Phenylboronic ester-modified anionic micelles for ROS-stimuli response in HeLa cell

Phenylboronic ester-modified anionic micelles for ROS-stimuli response in HeLa cell

Blog Article

Smart polymers as ideal drug nanocarriers have attracted much attention due to the effective Shoes - Boots drug delivery, internalization and release once triggered by intracellular stimuli, as well as reduced cytotoxicity.We here reported the anionic micelle consisting of copolymer (PEG-b-PAsp) and a PBE (Phenylboronic Ester) group grafted, which can achieve fast response to intracellular ROS and enhanced anti-tumor activity.With this, PEG-b-PAsp-g-PBE/DOX system showed better tumor growth inhibition when studied on HeLa cell lines with high level of intracellular ROS and its subcutaneous tumor models.Additionally, the administration blu-ray of PEG-b-PAsp-g-PBE/DOX did cause significantly lower systemic toxicity in comparison with free DOX.Hence, PEG-b-PAsp-g-PBE could be a highly efficient and safe nanocarrier to improve the efficacy of chemotherapeutic.